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Salgim is a stimulator of beta-2 adrenergic receptors. Bronchodilator effect is already in 4-6 minutes after inhalation of the drug, increases linearly, reaching a peak after 20-40 minutes, the duration of action is 4-5 hours.

At therapeutic doses also has a pronounced stimulating action on beta-2 adrenoceptors in blood vessels and myometrium. It has almost no effect on beta-1 adrenergic receptors of the heart. Inhibits histamine release from mast cells, leukotriene and prostaglandinwhere to buy testosterone enanthate, and other biologically active substances for a long time.

Suppresses bronchial hyperreactivity. Has a pronounced effect of bronchodilators, warning or arresting bronchospasm, reduces the resistance in the airways, increasing lung capacity. Positive effect on mucociliary clearance, stimulates the secretion of mucus, activates the function of the ciliated epithelium.

It stops the release of inflammatory mediators from mast cells and basophils, in the above privacy, anti-lgE-induced release of histamine, eliminates the suppression of antigen mucociliary transport and release of neutrophil chemotactic factor. It prevents the development of allergen-induced bronchospasm. May cause desensitization and reduction in the number of beta-adrenergic receptors, including lymphocytes. It has a number of metabolic effects: reduces the content of potassium in the plasma affects glycogenolysis and insulin release, has a hyperglycemic and lipolytic effect, increases the risk of acidosis.

The recommended therapeutic dosage has no negative where to buy testosterone enanthate effect on the cardiovascular system, it causes high blood pressure. To a lesser extent, as compared with the drugs of this group has a positive chrono – and inotropic effects. It is an extension of the coronary arteries. Has tocolytic effect: it lowers the tone and contractile activity of the myometrium. Part of the Salgima sodium benzoate has expectorant, and antifungal activity.

Pharmacokinetics

Inhalation 10-20% reaches the bronchial tubes and is gradually absorbed, the dose is absorbed after ingestion of the gastrointestinal tract. It undergoes first-pass metabolism in the liver and gut wall. The half -. about 4 hours Return with urine and bile, mainly in unchanged form (90%) or in the form of glucuronide.

Indications

Bronchial asthma (for relief of attacks of breathlessness), reversible airflow obstruction (prevention and treatment), including chronic obstructive pulmonary disease.

Contraindications

Hypersensitivity to the drug, coronary heart disease, severe heart failure, cardiac arrhythmias (paroxysmal tachycardia, ventricular arrythmia politopnye); myocarditis, heart defects, aortic stenosis, decompensated diabetes, glaucoma, seizures, which pyloroduodenal stenosis, kidney disease and liver in violation of their functions; pregnancy; concomitant use of nonselective beta-blockers.

With care – heart failure, hypertension, hyperthyroidism, pheochromocytoma, lactation.

Dosing and Administration

Salgim used by inhalation using where to buy testosterone enanthate a portable inhaler tsiklohalera individual in accordance with the instructions.

For relief of bronchospasm attack – 250-500 mcg salbutamol hemisuccinate (1-2 inhalation doses). To control the course of mild asthma – 1-2 inhalation doses 1-4 times a day; to monitor the course of the mean severity of bronchial asthma – 1-2 inhaled dose 1-4 times a day in combination with other antiasthmatic agents. To prevent asthma physical effort – for 20-30 minutes to load – 1-2 inhaled dose at the reception. Babies, for the removal of bronchospasm attack: single dose – 250 mcg; prevention – 250 mg / day; multiplicity of introduction – 3-4 times. For prevention of bronchospasm caused by exercise, – 250 g, before anticipated exercise. If you experience any discomfort in the mouth and sore throat after inhalation should rinse your mouth with water.

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