At therapeutic doses, it has a strong stimulating effect on the beta -2 adrenergic receptors of the bronchi, blood vessels and myometrium. Almost no effect on beta adrenergic receptors of the heart -1.
Inhibits histamine release testosterone enanthate from mast cells, leukotriene and prostaglandin D 2, and other biologically active substances for a long time.
It suppresses the early and late phase allergic reactions. Has a pronounced effect of bronchodilators, warning or arresting bronchospasm, reduces the resistance in the airways, increasing lung capacity. Positive effect on mucociliary clearance, stimulates the secretion of mucus, activates the function of the ciliated epithelium. Inhibits release of inflammatory mediators from mast cells and basophils, in particular, anti – lgE – induced release of histamine, removes suppression of antigen mucociliary transport and separation factor chemotaxis of neutrophils. It prevents the development of allergen-induced bronchospasm.
May cause desensitization and reduction in the number of beta – adrenergic receptors, in Vol. h. lymphocytes. It has a number of metabolic effects: reduces the content of potassium in the plasma affects glycogenolysis and insulin release, has a hyperglycemic and lipolytic effect, increases the risk of acidosis.
At the recommended therapeutic doses has no adverse effect on the cardiovascular system, it causes high blood pressure. To a lesser extent, as compared with the drugs of this group has a positive chrono – and inotropic effects. It is an extension of the coronary arteries. Has tocolytic effect: it lowers the tone and contractile activity of the myometrium.
It prevents the development of bronchospasm, improves breathing against the background of established bronchospasm, prevent nocturnal asthma.
Controlled release of salbutamol hemisuccinate after taking the pill inside allows you to create and maintain long-term effective therapeutic concentration in the blood. The therapeutic effect lasts for 12-14 hours. Connection with the plasma protein-10%.
It is well absorbed in the gastro – intestinal tract. The half-life -6 hours. It undergoes first-pass metabolism in the liver and gut wall. It reports the news, mainly in unchanged form and as an inactive metabolite fenolsulfatnogo.
testimony to application :
The drug is used testosterone enanthate to treat chronic obstructive pulmonary disease, including asthma, chronic obstructive bronchitis, pulmonary emphysema.
Hypersensitivity to the drug, coronary heart disease, hypertension, severe heart failure, arrhythmias (paroxysmal tachycardia, ventricular arrythmia politopnye); myocarditis, heart defects, aortic stenosis, decompensated diabetes, hyperthyroidism, pheochromocytoma, glaucoma, seizures, which pyloroduodenal stenosis, kidney disease and liver in violation of their functions; pregnancy, concomitant use of nonselective beta – blockers. Children under 12 years old.
process applications and dose :
Inside. As a rule, take one tablet Saltos 7.23 mg once a day in the afternoon. The daily dose can be increased to 2 – 3 tablets a day, in which case the first reception administered in the morning and the next at intervals of 12 or 8 hours, respectively. Tablets testosterone enanthate are swallowed whole without chewing.
side action :
The distal tremors, facial flushing, nervousness, anxiety, headache, dizziness, tachycardia, agitation, sleep disturbances, cramps, nausea, vomiting, dry mouth, anorexia, urinary retention, sweating, hyperglycemia, increased blood levels of free fatty acids , hypokalaemia, diarrhea, angioedema, allergic reactions (urticaria, erythema, swelling of the face), lower blood pressure, arrhythmia, myocardial ischemia, heart failure, pulmonary edema, collapse. The appearance of these symptoms you must tell your doctor.
Symptoms include nausea, vomiting, tachycardia, irregular heartbeat, the expansion of peripheral blood vessels, lowering blood pressure, hypoxemia, acidosis, hypokalemia, hyperglycemia, muscle tremor, headache, hallucinations, agitation. Treatment, removal of the drug, gastric lavage and symptomatic therapy (appointment of selective beta – blockers requires caution in patients with asthma from – the danger of severe bronchospasm).
Interaction from other drugs means :
Theophylline and other xanthines, while the application increases the risk of tachyarrhythmias; means for inhalation anesthesia, levodopa – heavy yhzheludochkovyh arrhythmias. Monoamine oxidase inhibitors, and tricyclic antidepressants increase the effect of salbutamol, may lead to a sharp decrease in blood pressure.
We do not recommend co-administration of salbutamol and non-selective beta – blockers (such as propranolol) of the – of the danger of severe bronchospasm. Diuretics and corticosteroids increase hypokalemic effect of salbutamol. It enhances the action of central testosterone enanthate nervous system stimulants, side effects on the heart of thyroid hormones. stabol