The rest of the dose remained deposited in an inhaler or oropharynx is swallowed and then on the mucosa. The fraction deposited on the mucosa of the respiratory tract, is absorbed into the pulmonary tissues and blood, but it is not metabolized in the lungs. The degree of binding of salbutamol to plasma proteins is approximately 10%. Salbutamol is metabolized in the liver and excreted primarily in the urine in unchanged form and in the form of phenolic sulphate . Swallowed part testosterone enanthate half life of the inhalation dose is absorbed from the gastrointestinal tract and undergoes active metabolism at the “first pass” through the liver, turning into the phenolic sulphate. Unchanged salbutamol and conjugate are excreted primarily in the urine. The half-life of salbutamol 4-6 hours. Excreted by the kidneys partly in unchanged form and partly as an inactive metabolite 4′-O-sulphate (phenolic sulphate). A minor part is excreted in the bile (4%), with the feces. Most of the salbutamol dose excreted within 72 hours.
1. Bronchial asthma:
– relief of asthma attacks, including an exacerbation of bronchial asthma heavy currents;
– prevention of attacks of bronchospasm associated with exposure to the allergen, or caused by physical activity;
– use as a component in long-term maintenance treatment of asthma.
2. Chronic obstructive pulmonary disease, accompanied by reversible airway obstruction, chronic bronchitis.
– Hypersensitivity to any component of the formulation.
– Children under 2 years old.
with a history marked tachyarrhythmia, myocarditis, heart defects, aortic stenosis, coronary heart disease, severe chronic heart failure, hypertension, hyperthyroidism, pheochromocytoma, decompensated diabetes, glaucoma, epipripadki, renal or hepatic insufficiency, concomitant use of nonselective ß adrenoblokatorov, pregnancy, lactation.
Pregnancy and lactation
Pregnant women salbutamol can be given only if the expected benefit to the patient outweighs the potential risk to the fetus. Probability of penetration of salbutamol in breast milk is not possible, so it is not recommended for nursing mothers unless the expected benefit to the most patient outweighs the potential risk to the child. No data is provided if present in breast milk salbutamol harmful effect on the newborn.
DOSAGE AND ADMINISTRATION
Salbutamol aerosol for inhalation dose of testosterone enanthate half life 100 micrograms / dose is intended for administration by inhalation.
To solve the problem of increasing the dose or frequency of use of the drug can only be a doctor.
Do not use the drug more than 4 times a day. The need for frequent application of maximal doses or in a sudden increase in the dose indicates a deterioration of the disease. Adults (including elderly patients) . Long-term maintenance therapy in asthma in the complex therapy: The recommended dose is 200 mg (2 inhalations) 4 times a day. Cupping bronchospasm: the recommended dose is 100-200 mg (1-2 inhalations). Preventing attacks of bronchospasm, related to exposure to allergen or exercise-induced: the recommended dose is 200 mg (2 inhalations) for 10-15 minutes before exposure to a provoking factor. Children. Long-term maintenance therapy in asthma and in the complex therapy: The testosterone enanthate half life recommended dose is 200 mcg ( 2 inhalations) 4 times a day. cupping bronchospasm: the recommended dose is 100-200 mg (1-2 inhalations). Preventing attacks of bronchospasm associated with exposure to the allergen or exercise-induced: the recommended dose is 100-200 mg (1-2 inhalation) for 10-15 minutes before exposure to a provoking factor.