buy testosterone enanthate

Has a local anti-inflammatory effect due to inhibition of neutrophil lipoxygenase and the synthesis of prostaglandins and leukotrienes. Retards migration, degranulation, phagocytosis of neutrophil, as well as immunoglobulin secretion by lymphocytes. Antibacterial activity against Escherichia coli and some cocci (shown in the colon). It has an antioxidant effect (due to the ability buy testosterone enanthate to bind to free oxygen radicals and destroy them). From mesalazine tablets released in the terminal small intestine and colon. Rectal suppositories and suspension act in the distal third of the colon and rectum.

 

Pharmacokinetics
Approximately 30-50% of an oral dose is absorbed mainly in the small intestine. Mesalazine undergoes acetylation in the intestinal mucosa, in the liver, forming N-acetyl-5-aminosalicylic acid. Communication with plasma proteins – 43%, a N- acetyl-5-aminosalicylic acid-73-83%. Mesalazine and its metabolite do not penetrate the blood-brain barrier and penetrate into breast milk. Mesalazine and its metabolites are excreted in urine and feces.

Indications tablets enteric coated Ulcerative colitis (UC) and Crohn’s disease. Suppositories rectal Ulcerative Colitis with lesions of the rectum (ulcerative proctitis). The suspension rectal Ulcerative Colitis with the defeat of the distal colon and rectum.

Contraindications:
Hypersensitivity, blood diseases, gastric ulcer and buy testosterone enanthate duodenal ulcer (exacerbation), deficiency of glucose-6-phosphate dehydrogenase, gemorrargichesky diathesis, severe renal / hepatic insufficiency, during lactation, the last 4 weeks of pregnancy, children’s age (up to 2 years). Precautions – pregnancy (1 trimester), liver and / or kidney failure.

Use during pregnancy and lactation
is known that mesalazine crosses the placental barrier, however, limited experience with the drug in pregnant women does not allow to evaluate the possible side effects. If pregnancy should be prescribed the drug only in cases where the positive effect of its implementation outweigh the risk to mother and child. Mesalazine is excreted in breast milk at a concentration lower than in the blood of women, while the metabolite – acetyl mesalazine – is detected in a similar or higher concentration. If necessary, use during lactation should decide the issue of termination of breastfeeding.

Dosage and administration: Tablets, enteric-coated tablets, 400 mg and 800 mg tablets should be taken whole, without chewing, for at least one hour before a meal with a glass of liquid. Stage exacerbation Adults: Dose selected individually, usually – 800 mg 3 times a day . The maximum dose – 4 g per day in divided doses. The children weighing more than 40 kg dosage is buy testosterone enanthate adjusted individually, a maximum of 50 mg per 1 kg of body weight per day. Maintenance therapy Adults: dose adjusted individually, normally 400 mg four times a day ., or 800 mg 2 times a day children weighing more than 40 kg dosage is adjusted individually, maximum – 30 mg per 1 kg of body weight per day.

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